You first meet Hana in Chapter 2 at the boutique where you are looking for a dress for the Masquerade Ball. You walk in and accidentally see Hana in her underwear. Depending on your reaction, you can gain relationship or romance points with her. During Book 1, you two become friends although the extent of your friendship is dependent on your choices. She helps you navigate through courtly decorum and procedures, admitting to you in Chapter 7's premium scene that her parents suggested getting close to you as a way to help her get close to Liam and become part of his inner circle. Regardless of their feelings, she tells you that she enjoys spending time with you and later becomes downhearted at the prospect of you marrying Liam and her being labeled a failure again by her parents. In Chapter 14, you encourage her to stand up to her parents but the consequences of her defying their wishes catch up to her in Chapter 17 when her parents send a messenger to the Coronation ball to let her know that she will be leaving Cordonia afterward.
In The Royal Romance, Book 1, Hana becomes friends with Kiara and Penelope, the three becoming closer when they fall out of the running in the competition to become \"Liam\"'s fiancee. In Book 3, if you proclaim your love for Hana and choose her as your fiancee, she chooses Kiara as her maid of honor. In The Royal Finale, Chapter 15, if you decide to have a compliment circle in the conservatory, Kiara tells Hana that her hot chocolate is extraordinary and divine.
Biochemical features of Elp3. (a) Illustrations of the Elp3-dependent cm5U modification reaction (left) and the crystal structure of the acetyl-CoA binding pocket of DmcElp3 with desulfo-CoA (right, PDB: 6IA6). The components in the cm5U reaction are as indicated. The ligand contacting residues are labeled, while the conserved lysine (Lys77 in DmcElp3) is highlighted in red. (b) Schemes of the proposed tRNA-triggered acetyl-CoA hydrolysis of Elp3 (left) and Gcn5-mediated protein acetylation mechanism (right). The modifiable U34 and reactive K14 of histone H3 peptide are colored in red. For a clearer presentation, the α1 and α2 helices of TtGcn5 are shown in a transparent style. Acetyl-CoA, shown in cartoon, is modeled in the binding pockets of Elp3 or Gcn5, whereas the chemical structure of acetyl-CoA is shown on the top and the reactive carbons are highlighted in an orange circle (acetyl radical for cm5 modification) or purple circle (carbonyl group of the thioester of acetyl-CoA). The reactive sites of cm5U34 and Ac-Lys are both colored in red and present the C-C bond for the cm5 addition and the C-N bond for the acetyl-lysine addition, respectively.
Elongator-mediated tRNA modification and clinically relevant mutations of human Elp3. (a) Schemes of disease-related mutations and Elongator-mediated tRNA modification cascade. The reported changes in human Elp3 from neurodegenerative diseases (ND) are indicated, while those of tumors (data were retrieved from COSMIC, ICGC, and TCGA databases) are shown in the Venn diagram. tRNA (black) binds to one lobe of Elp123 that is involved in Elp456 dynamic interactions. Elp3 hydrolyzes acetyl-CoA and cleaves SAM for the cm5 addition on U34. The cm5U34 is then converted to the derivatives by other enzymes. (b) Summary of reported alterations and PTM sites of mouse Elp3 (p-Ser161) and human Elp3 (p-Tyr202 and m-Lys229). The residue numbers and domains of human Elp3 are indicated. The locations of the alterations are as listed in the cartoon representation and they are color-coded according to which database resources are found. The experimentally verified residues are indicated with an asterisk. The identified PTM sites (solid circles) of Elp3 as well as the catalytic residues for acetyl-CoA binding/hydrolysis (open square) in Elp3 are listed.
The new company will continue development on the Fate/Grand Order smartphone game, and the production committee of the game will change to be Aniplex, Notes (the corporate name of the Type-Moon creative circle), and the new as-yet unnamed company.
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